Speaking exclusively to the BBC, he said he should not be associated with the anti-vax movement, but supported an individual's right to choose.
Djokovic was asked if he would sacrifice taking part in competitions such as Wimbledon and the French Open over his stance on the vaccine.
"Yes, that is the price that I'm willing to pay," he said.
The 20-time Grand Slam winner was deported from Australia last month after the government cancelled his visa in a row over his vaccine status.
Djokovic, who is the world's number one men's tennis player, said he had obtained a medical exemption to enter the country to play in the Australian Open as he had recently recovered from Covid-19.
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