The 27-year-old was also hugged by Rory McIlroy on the 18th green as he became just the third Englishman in 52 years to win the sport's second oldest major.
Fitzpatrick shot a two-under 68 for a six-under total to beat world number one Scottie Scheffler (67) and Will Zalatoris (69) in a gripping battle that went to the final hole.
"It's what you grow up dreaming of," said Fitzpatrick. "It's something I've worked so hard for for such a long time. I've got to give myself credit: I had so much patience."
His win will be remembered for the stunning shot he played from a fairway bunker on the 18th.
In scenes reminiscent of Sandy Lyle's final-hole bunker shot on his way to winning the 1988 Masters at Augusta National, Fitzpatrick launched a high cut at the green, the ball landing 20 feet beyond the flag and spinning a couple of feet closer.
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